Waldenstrom's macroglobulinaemia treated with cylophosphamide and chlorambucil

Waldenström's macroglobulinaemia treated with cylophosphamide and chlorambucil.

A case of primary macroglobulinaemia of Waldenström is described in which prolonged treatment with the alkylating agents of cyclophosphamide and chlorambucil led to a sustained reduction in the concentration of circulating macroglobulin together with a concurrent improvement in the patient's symptoms.

Induction of mutant lymphocytes in cyclophosphamide- and chlorambucil-treated patients.

Monitoring patients treated with single antineoplastic agents is aiding our understanding of what hazard these drugs pose in vivo. In this study, the frequency of mutant 6-thioguanine-resistant (TG(R)) peripheral blood lymphocytes was monitored before treatment and for < or =35 weeks after treatment of patients with cyclophosphamide (CP) or chlorambucil (CAB). The mean mutant frequency before t...

Mononeuritis multiplex in a patient with macroglobulinaemia.

A case is described of a 73 year old male with Waldenström's macroglobulinaemia and hyperviscosity in association with neurological abnormalities, the Bing-Neel syndrome. The relationship of the clinical features to changes in serum viscosity and the response to therapy with plasmapheresis and chlorambucil are discussed.

Macroglobulinaemia and steatorrhoea.

Waldenström's macroglobulinaemia presenting with nephrotic syndrome.

Minimal change nephropathy (MCN) is a major cause of nephrotic syndrome in both children and adults. It is characterised by normal appearing glomeruli by light microscopy and the absence of immunoglobulin deposits by immunoflorescence microscopy. On electron microscopy there is diffuse fusion of the epithelial foot processes. MCN is suggested to be caused by a T-cell or B-cell dysfunction and/o...